When chemists need to separate one chiral molecule from a mixture of enantiomers—for instance, when synthesizing potential drug molecules—they often turn to high-performance liquid chromatography ...

Many chemical compounds exist in two variants, called enantiomers. These consist of the same elements but act as mirror images of each other. In reference to our hands, which are also mirror images, ...

From 2001 to 2011, the US Food and Drug Administration approved 9 single-enantiomer drugs with racemic precursors. None showed pre-approval evidence of improved efficacy over the racemic precursor. We ...

Enantiomers are two molecules with the same chemical composition, mirror images of each other, which do not overlap. Produced in equal quantities during a chemical reaction, they may exhibit opposite ...

A mixture of a both enantiomers of carvone and both enantiomers of an orange ferrocene probe can be loaded into this device. Each enantiomer comes out the other end of the device as a separate ...

New biocatalytic and chemocatalytic routes to chiral intermediates and developments in simulated-moving-bed and supercritical-fluid chromatography for resolving racemic mixtures. The prevalence of ...

Thalidomide, one of the most infamous drugs of all, caused severe birth defects in the children of pregnant women who took the drug for nausea in the 1950s. Its story has been repeated over and over – ...

Single-enantiomer drugs account for nearly 40% of the global pharmaceutical market. The author analyzes the current market for single-enantiomer drugs, their role as a generic drug defense strategy, ...