Many scientific datasets are compositional in nature. Important biological examples include species abundances in ecology, cell-type compositions derived from single-cell sequencing data, and amplicon ...

Here we present a statistical approach to disentangle treatment and placebo effects using instrumental variables 14,15,16 in randomized experiments. An instrumental variable (IV) is statistically ...

In the article that accompanies this editorial, Lu et al 5 conducted a systematic review on the use of instrumental variable (IV) methods in oncology comparative effectiveness research. The main ...