Bombshell review of dementia treatment makes worrying claim about 'wonder drugs'

EXCL: As Cochrane review found two dementia drugs had only a "trivial" effect, Prof Rob Howard and Prof Sir John Hardy ...
AHA/ASA Journals

Targeting Interleukin-8–Mediated Cellular Crosstalk Reverses Hypertrophic Cardiomyopathy and Cardiac Fibrosis in Noonan Syndrome

BACKGROUND: Genetic variants in components or regulators of the RAS-MAPK signaling pathway are causative for severe and early-onset hypertrophic cardiomyopathy (HCM) in patients with Noonan syndrome ...
eLife

Long-range neural pathways for octopus chemotactile processing revealed from periphery-to-brain by centimeter-field microCT

In this study, the authors use microCT to image an intact hatchling octopus and segment major organ systems, including the vascular, respiratory, digestive, and nervous systems. The resulting dataset ...
Journal of Neurology, Neurosurgery and Psychiatry (JNNP)

Midlife plasma proteomic profiles indicate altered amyloid and tau processing in former elite rugby players

Background Contact sports, including rugby union, are associated with higher rates of neurodegenerative dementia, due to ...