AHA/ASA Journals

Defective Trophoblast Differentiation, Endothelial Dysfunction, and Immune Dysregulation in Preeclampsia Coalesce on a Placental VGLL3-Centered Gene Netw…

BACKGROUND: Preeclampsia affects approximately 1 in 10 pregnancies, leading to severe complications and long-term health ...
Microsoft

Scalable nonparametric clustering with unified marker gene selection for single-cell RNA-seq data

Clustering is commonly used in single-cell RNA-sequencing (scRNA-seq) pipelines to characterize cellular heterogeneity. However, current methods face two main limitations. First, they require ...
News Medical

Single-cell RNA sequencing reveals accelerated T cell aging in viral infections

A new research paper was published in Volume 18 of Aging-US on February 8, 2026, titled "Single-cell transcriptomics reveal intrinsic and systemic T cell aging in COVID-19 and HIV." In this study, ...
GitHub

Functional Transcriptomics Visualization Workflow

A comprehensive workflow for visualization and functional analysis of differentially expressed genes (DEGs) from RNA-seq experiments. This repository provides reproducible scripts for generating ...
The Scientist

Long-Read RNA Sequencing Reveals a Regulatory Role for Splicing in Immunotherapy Responses

Immunotherapy has been a revolutionary breakthrough for cancer therapeutics, but it is still hampered in that it only benefits certain patients. Moreover, the molecular determinants of immunotherapy ...
EurekAlert!

New review decodes transcriptomics: bulk vs. single-cell RNA sequencing

A comprehensive review article titled “Bioinformatics perspectives on transcriptomics: A comprehensive review of bulk and single-cell RNA sequencing analyses,” published in Quantitative Biology, ...
GitHub

A Python package for generating virtual cells using diffusion models from single-cell RNA sequencing data.

CellDiffusion provides a generalized implementation of diffusion models for single-cell RNA sequencing data. It allows users to generate synthetic virtual cells from AnnData objects, providing a ...
Baylor College of Medicine

Researchers show benefit of ultra-deep RNA sequencing in Mendelian disorder diagnostics

RNA sequencing (RNA-seq) is a powerful tool in diagnosing Mendelian disorders, but the optimized sequencing depth for this technology has not yet been determined. In a new study published in the ...
IEEE

kmmDE: a Non-parametric Method for Differential Expression Analysis of Time-course RNA-seq Data Using Maximum Mean Discrepancy

Abstract: Accurately identifying differentially expressed genes from time-course RNA-Seq data is essential for understanding the dynamics of transcriptome changes during biological processes. Although ...
ahajournals.org

Human Single-Nucleus RNA Sequencing Identifies CD47 as a Therapeutic Target for Doxorubicin-Induced Cardiomyopathy

Doxorubicin cardiomyopathy (DoxCM) remains a significant clinical problem, but its underlying mechanisms remain incompletely understood. Identifying DoxCM mechanisms can lead to therapeutic ...
Frontiers

Integrating single-cell RNA-seq, bulk RNA-seq and network pharmacology reveals protective effect of salidroside in peritoneal dialysis-associated peritoneal fibrosis

Salidroside (2- (4-Hydroxyphenyl) ethyl β-D-glucopyranoside, SAL) is a bioactive compound present in Rhodiola rosea L., exhibiting diverse pharmacological properties such as anti-inflammatory and anti ...